Researchers from the University of Southern Denmark have discovered that the skin is capable of communicating with the liver. The discovery has surprised the scientists, and they say that it may help our understanding of how skin diseases can affect the rest of the body.
Professor Susanne Mandrup and her research group in collaboration with Nils Færgeman’s research group at the Department of Biochemistry and Molecular Biology at the University of Southern Denmark was actually studying something completely different when they made the groundbreaking discovery: That the skin, which is the body's largest organ, can "talk" to the liver.
"We have shown that the skin affects the metabolism in the liver, and that is quite a surprise”, say Susanne Mandrup and Ditte Neess, a former student in the Mandrup research group and now laboratory manager in Professor Nils Færgeman’s group.
The phenomenon was observed in the researcher’s laboratory mice. The Mandrup and Færgeman groups work with so-called knock-out mice, in which a specific fat binding protein called acyl CoA binding protein has been removed (knocked out). Some knock-out mice produced by the researchers had a strange greasy fur, and they had difficulties being weaned from their mother. In the weaning period they gained less weight and showed a failure to thrive. Analyses also showed that the mice accumulated fat in the liver at weaning.
"At first we thought that the fat accumulation in the liver was linked with the fact that the gene was missing in the liver of the knock-out mice. But this was ruled out by a series of studies, and we had to find another explanation”, says Ditte Neess.
She and her colleagues took another look at the weak knock-out mice with the tousled fur. Their fur was greasy, and they had a leaky skin from which they lost more water than normal mice.
"When they lose water, they also lose heat. We therefore asked ourselves whether this water and heat loss could be the reason why the mice accumulated fat in the liver and became weak when weaned from their mother”, says Ditte Neess.
To clarify this, the researchers made some mice that lacked the fat binding protein only in the skin. Similar to the full knockouts these mice had difficulties after weaning and accumulated fat in the liver. So this showed that the lack of the fat-binding protein in the skin was sufficient to induce accumulation of fat in the liver.
To get to the bottom of how a defect in the skin “talks” to the liver, the researchers decided to cover the mice with vaseline. This would prevent water evaporating from the skin and thus stopping the heat loss. As a result the fat accumulation in the liver disappeared. But as vaseline contains fat, that could theoretically be absorbed by the skin or ingested by the mice, the researchers were a little unsure if there were side effects from the vaseline. A student proposed to cover the mice with liquid latex, which she found in a local sex shop.
Having covered the mice in blue latex the researchers saw that fat accumulation in the liver again disappeared.
"We believe that the leaking of water from the skin makes the mice feel cold, and that this leads to breaking down of fat in their adipose (fat) tissue. The broken down fat is then moved to the liver. The mice move energy from the tissues to the liver”, Susanne Mandrup and Ditte Neess explain.
About the Mandrup Group
The Mandrup group's research is important for understanding obesity and type II diabetes.
The work is about understanding the molecular mechanisms underlying the regulation of genes in mammalian cells. The group is specifically interested in the factors that regulate the development of stem cells into fat cells and the factors that convey metabolic signals including insulin-producing β - cells of the pancreas. In addition, research in the lipid-binding protein, acyl -CoA binding protein (ACBP) using mouse models that have been stripped of this gene.
Photos and film of mice in blue latex: Scientists covered the mice with blue latex to prevent evaporation from the skin and thus stop the heat loss. With this loss the mice stopped accumulating fat in the liver. This shows that the skin is communicating with the liver. Photos: Birgitte Svennevig/SDU. Film: Henrik Gautier/SDU.
Ref: Ditte Neess, Signe Bek, Maria Bloksgaard, Ann-Britt Marcher, Nils J. Færgeman, Susanne Mandrup: Delayed Hepatic Adaptation to Weaning in ACBP/Mice Is Caused by Disruption of the Epidermal Barrier. Cell Report. Dec 5 2013.
06.12.2013Back to the news list