OBS! Vi søger netop nu motiverede molekylærbiologi-, biomedicin- og computational biomedicine-studerende til bachelor- eller specialeprojekter i foråret 2024.
Skriv til Kim Ravnskjaer (ravnskjaer@bmb.sdu.dk) hvis du er interesseret eller har spørgsmål til vores projekter.
NB! Spring 2024 project openings are now available for motivated students of molecular biology, biomedicine, and computational biomedicine at the Bachelor’s or Master’s level.
Please contact Kim Ravnskjaer (ravnskjaer@bmb.sdu.dk) with your expression of interest or any questions you may have to our projects.
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Research in our lab is aimed at understanding the cellular interactions shaping and mediating microvascular functions in tissue health and disease. Their insights into vascular and perivascular plasticity will form the basis for better disease monitoring and of innovative solutions for restoring vascular function and integrity.
Non-alcoholic steatohepatitis (NASH) is a disease in focus in our laboratory. NASH is a closely linked to obesity and type-II diabetes, and is defined by hepatic steatosis, cellular turnover, inflammation, and profound microvascular remodeling. Advanced NASH leads to massive scarring (fibrosis) of the liver and is a leading cause of liver cirrhosis and hepatocellular carcinoma. Despite the prevalence and severity of NASH, little is known about the molecular mechanisms driving NASH development.
In our projects, we investigate how cells in tissues interact and undergo transitions during the progression and regression of disease. We elucidate disease mechanism by applying advanced functional genomics, bioimaging, biochemical and physiological measurements in the study of patient biopsies and animal models. Key technologies include single-cell and spatially resolved multiomics, transgenic mouse models, viral gene delivery, and a host of imaging techniques. Our computational biology platform allows us to explore large data sets to identify gene regulatory networks underlying disease.
Current projects
- Gene regulatory networks in the progression and regression of human NASH
- Cellular crosstalk and metabolic regulation in advanced disease
- Perivascular GPCR signaling in healthy and fibrotic tissue
- Microvascular transport and barrier function in health and disease
We are always interested in hearing from motivated students and postdocs. Please contact us at ravnskjaer@bmb.sdu.dk.