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Trevor Owens For CV, list og publications, publicity, international netvork etc. |
Research interests
We study pathogenic mechanisms of inflammatory diseases of the central nervous system (CNS), such as multiple sclerosis and neuromyelitis optica. Such mechanisms are often relevant to degenerative diseases such as Alzheimers disease.
We study interactions between the immune system and glial cells of the nervous system, both those that lead to pathology as well as with regulatory and protective outcomes. We are particularly interested in translating clinical observations to experimental analyses. Our goal is to understand how innate and adaptive immune cells and mediators contribute to neurological disease.
Methods and techniques
We mainly focus to mouse models and we use histological, flow cytometric, molecular and tissue culture methods to evaluate immuno- and neuropathogenesis in genetically-modified mice.
Collaborations within SDU
Bente Finsen and Kate Lykke Lambertsen (NB IMM) – Microglia a key to brain rejuvenation
Ulrike Muscha Steckelings (CVR IMM) – Protective role for Angiotensin Type 2 Receptor in neuroinflammation
Martin Wirenfeldt Nielsen (Pathology, OUH) – Pathology of MS-protective fetal and maternal tissue
Mads Thomassen (Clinical Genomics, OUH) – Transcriptional analysis of glial cells
Jesper Grud Skat Madsen (Biochemistry Molecular Biology) - Analysis of single cell transcriptomics
Grith Lykke Sørensen (CVR IMM) – Novel biomarkers for NMOSD
Support received from
Scleroseforeningen
Independent Research Fund Denmark
Lundbeckfonden
EU Marie-Sklodowska Curie Actions
Information for students
We welcome applications from motivated and interested students, at all levels.