In work package 2 we focus on deciphering the cellular dynamics and microenvironmental interactions in the liver during the progression and regression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). MASLD is commonly associated with obesity and dyslipidemia and characterized by liver steatosis. Liver steatosis may over time lead to Metabolic Dysfunction-Associated Steatohepatitis (MASH), a severe inflammatory condition associated with cellular dysfunction and the formation of hepatic scar tissue.
By leveraging single-cell and spatial omics technologies, we aim to map liver cell diversity and understand interactions among various cell types at different disease stages, with particular attention to gender differences.
Additionally, experimental models will be used to identify and test key factors driving disease progression and potential recovery. A critical aspect of our research is examining liver responses to weight loss, including both rapid and gradual approaches, to uncover predictive factors for recovery from MASLD.
Expected outcomes of this work package include a comprehensive map of cellular changes in MASLD, identification of pivotal molecular drivers, and insights into weight loss effects on liver health.
