Publications

2020

Siersbæk R§, Scabia V, Nagarajan S, Chernukhin I, Papachristou EK, Broome R, Johnston SJ, Joosten SEP, Green AR, Kumar S, Jones J, Omarjee S, Alvarez-Fernandez R, Glont S, Aitken SJ, Kishore K, Cheeseman D, Rakha EA, D'Santos C, Zwart W, Russell A, Brisken C, Carroll JS§ (2020). IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis. Cancer Cell. 14;38(3):412-423.e9. PMID: 32679107 DOI: 10.1016/j.ccell.2020.06.007

Nagarajan S, Rao SV#, Sutton J#, Cheeseman D#, Dunn S, Papachristou EK, Prada JG, Couturier DL, Kumar S, Kishore K, Chilamakuri CSR, Glont SE, Archer Goode E, Brodie C, Guppy N, Natrajan R, Bruna A, Caldas C, Russell A, Siersbæk R, Yusa K, Chernukhin I, Carroll JS (2020). ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response. Nat Genet. 52(2):187-197. PMID: 31913353. DOI: 10.1038/s41588-019-0541-5

Glont SE#, Papachristou EK#, Sawle A, Holmes KA, Carroll JS§, Siersbaek R§ (2019). Identification of ChIP-seq and RIME grade antibodies for Estrogen Receptor alpha. PLoS One. 14(4):e0215340. PMID: 30970003. DOI: 10.1371/journal.pone.0215340

Siersbæk R§, Kumar S, Carroll JS§ (2018). Signaling pathways and steroid receptors modulating estrogen receptor α function in breast cancer. Genes Dev. 32(17-18):1141-1154. PMID: 30181360. DOI: 10.1101/gad.316646.118

Papachristou EK, Kishore K#, Holding AN#, Harvey K, Roumeliotis TI, Chilamakuri CSR, Omarjee S, Chia KM, Swarbrick A, Lim E, Markowetz F, Eldridge M, Siersbaek R§, D'Santos CS§, Carroll JS§ (2018). A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes. Nat Commun. 9(1):2311. PMID: 29899353. DOI: 10.1038/s41467-018-04619-5

Michaloglou C#, Crafter C#, Siersbaek R, Delpuech O, Curwen JO, Carnevalli LS, Staniszewska AD, Polanska UM, Cheraghchi-Bashi A, Lawson M, Chernukhin I, McEwen R, Carroll JS, Cosulich SC (2018). Combined Inhibition of mTOR and CDK4/6 Is Required for Optimal Blockade of E2F Function and Long-term Growth Inhibition in Estrogen Receptor-positive Breast Cancer. Mol Cancer Ther. 17(5):908-920. PMID: 29483206. DOI: 10.1158/1535-7163.MCT-17-0537

Sarusi Portuguez A, Schwartz M, Siersbaek R, Nielsen R, Sung MH, Mandrup S, Kaplan T, Hakim O (2017). Hierarchical role for transcription factors and chromatin structure in genome organization along adipogenesis. FEBS J. 284(19):3230-3244. PMID: 28755519. DOI: 10.1111/febs.14183

Siersbæk R#, Madsen JGS#, Javierre BM#, Nielsen R#, Bagge EK, Cairns J, Wingett SW, Traynor S, Spivakov M, Fraser P§, Mandrup S§ (2017). Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation. Mol Cell. 66(3):420-435.e5. PMID: 28475875. DOI: 10.1016/j.molcel.2017.04.010

Rakhshandehroo M, Gijzel SM#, Siersbæk R#, Broekema MF#, de Haar C, Schipper HS, Boes M, Mandrup S, Kalkhoven E (2014). CD1d-mediated presentation of endogenous lipid antigens by adipocytes requires microsomal triglyceride transfer protein. J Biol Chem. 289(32):22128-39. PMID: 24966328. DOI: 10.1074/jbc.M114.551242

Siersbæk R, Baek S, Rabiee A, Nielsen R, Traynor S, Clark N, Sandelin A, Jensen ON, Sung MH, Hager GL, Mandrup S (2014). Molecular architecture of transcription factor hotspots in early adipogenesis. Cell Rep. 7(5):1434-1442. PMID: 24857666. DOI: 10.1016/j.celrep.2014.04.043

Siersbæk R#, Rabiee A#, Nielsen R, Sidoli S, Traynor S, Loft A, Poulsen LC, Rogowska-Wrzesinska A, Jensen ON, Mandrup S (2014). Transcription factor cooperativity in early adipogenic hotspots and super-enhancers. Cell Rep. 7(5):1443-1455. PMID: 24857652. DOI: 10.1016/j.celrep.2014.04.042

Madsen MS, Siersbæk R, Boergesen M, Nielsen R, Mandrup S (2014). Peroxisome proliferator-activated receptor γ and C/EBPα synergistically activate key metabolic adipocyte genes by assisted loading. Mol Cell Biol. 34(6):939-54. PMID: 24379442. DOI: 10.1128/MCB.01344-13

Siersbæk R, Nielsen R, Mandrup S (2012). Transcriptional networks and chromatin remodeling controlling adipogenesis. Trends Endocrinol Metab. 23(2):56-64. PMID: 22079269. DOI: 10.1016/j.tem.2011.10.001

Siersbæk R, Nielsen R, John S, Sung MH, Baek S, Loft A, Hager GL§, Mandrup S§ (2011). Extensive chromatin remodelling and establishment of transcription factor 'hotspots' during early adipogenesis. EMBO J. 30(8):1459-72. PMID: 21427703. DOI: 10.1038/emboj.2011.65

Aagaard MM#, Siersbæk R#, Mandrup S (2011). Molecular basis for gene-specific transactivation by nuclear receptors. Biochim Biophys Acta. 1812(8):824-35. PMID: 21193032. DOI: 10.1016/j.bbadis.2010.12.018

Siersbaek R, Nielsen R, Mandrup S (2010). PPARgamma in adipocyte differentiation and metabolism--novel insights from genome-wide studies. FEBS Lett. 584(15):3242-9. PMID: 20542036. DOI: 10.1016/j.febslet.2010.06.010

Nielsen R#, Pedersen TA#, Hagenbeek D#, Moulos P, Siersbaek R, Megens E, Denissov S, Børgesen M, Francoijs KJ, Mandrup S§, Stunnenberg HG§ (2008). Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis. Genes Dev. 22(21):2953-67. PMID: 18981474. DOI: 10.1101/gad.501108

# Equal contribution, § Co-correspondence.

Back to Siersbæk Group