News from Translational Biology
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June 2022
New publication online
DNA replication is a highly regulated process in eukaryotic cells, and it is coordinated by the replisome, a multi-protein complex that ensures the correct duplication of the genetic material. Eukaryotic cells are also equipped with surveillance mechanisms coupled to the replisome to prevent the transfer of damaged DNA to the daughter cells. Our latest results provide novel insights into the critical mechanisms which control DNA synthesis and the DNA replication checkpoint by showing that CK2a is essential for maintaining the stability of the replisome machinery and for optimal activation of the ATR-CHK1-mediated signalling pathway upon induction of DNA replication stress.
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March 2022
Mohammad Aarif Siddiqui receives DKK 1.700.000
The Lundbeck Foundatioon supported the postdoc project entiteled ‘Targeting splicing for the chemo-prevention of brain metastases’ The project aims to develop a therapeutic strategy against brain metastasis by altering splicing of thymidylate synthase (TS) mRNA using splice switching oligonucleotides (SSOs).
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March 25 2021
Congratulations Paolo
Congratulations to Paolo Ceppi on receiving a 10m DKK Ascending Investigator Grant from the Novo Nordisk Foundation for his work on 'Understanding and targeting the polyol pathway and fructose dependency of non-small-cell lung carcinoma'
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March 16 2021
New publication online
We applied metabolomics and lipidomics to examine temporal regulation of metabolism during starvation in wild‐type Caenorhabditis elegans and in animals lacking the transcription factor HLH‐30. Our findings show for the first time that starvation alters the abundance of hundreds of metabolites and lipid species in a temporal‐ and HLH‐30‐dependent manner.
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March 2 2021
New publication online
Cellular plasticity-regulating process of EMT as a model to show the efficacy of a fluorescent sensor to separate cells with distinct EMT signatures, based on miR-200b/c activity. The system was combined with a CRISPR-Cas9 screening platform to identify miR-200b/c upstream regulating genes. The sensor allows to infer miRNAs properties, as profiling of sorted cells indicated miR-200b/c as a molecular switch between EMT differentiation and proliferation, and suggested a role for metabolic enzymes in miR-200/EMT regulation.
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January 27 2021
PhD defence, Lise
Congratulations! Lise Lolle Holm successfully defended her PhD thesis today. Thanks to the excellent opponents, who did a great job. Prof. Javier F. Caceres (University of Edinburgh), Asc.Prof. Xavier Roca, (Nanyang Technological University) and Chair of committee Prof. Jan Wilhelm-Kornfeld (University of Southern Denmark).
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January 10 2021
New publication online
ACBP-/- mice and skin-specific ACBP-/- mice exhibit increased energy expenditure, increased food intake, browning of the iWAT, and resistance to diet-induced obesity. The metabolic phenotype, including browning of the iWAT, was reversed by housing the mice at thermoneutrality or β-adrenergic blocking. Interestingly, these findings were phenocopied in flaky tail mice.
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December 17 2020
New publication online
In this study, we show that the splicing factor SRSF10, which is particularly abundant in neuronal tissue, binds to ISS-N1, and that the long and short isoforms of SRSF10 inhibit SMN splicing with different strength correlating with the length of their RS domain. Our results suggest that the ratio between the SRSF10 isoforms is important for SMN splicing regulation.
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December 16 2020
Best Christmas Decoration 2020
This years contest of decorating the best Christmas office at the Department was expanded to also include home offices. Thomas from the Translational Biology section did a great job decorating his home office. Therefore he won the honorablel 'Gertrud Sand' price 2020.
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November 6 2020
Online Bingo
Today we met for a corona friendly social activity in the Translational Biology section. We played bingo online on zoom with Thomas as a great bingo host, many nice prices and great time together, while separated.
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August 9 2020
SDU moves
SDU moves is an initiative that encourages all SDU employees to be physically active during work hours. In the Translational Biology section we all went for a nice long walk together.
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March 12 2020
Corona virus - SDU closed
SDU follows the recommendations from the danish authorities and is therefore physically closed through May 10 2020. Staff and students are working from home. Please contact us by email or phone.
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February 28, 2020
August Krogh on Tour, Christopher Ellis
Today 'August Krogh on Tour' presented Professor Christopher Ellis from University of Western Ontario, Canada. Professor Ellis gave a very interesting talk entiteled Krogh’s Insights About the Microcirculation - Relevant a Century Later.
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February 19, 2020
Fastelavn 2020
Today we celebrated the annual 'Fastelavn' tradition and many people dressed up in very nice costumes.
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February 12, 2020
PhD defence, Anne-Mette
Today Anne-Mette Hartung defend her PhD Thesis entiteled 'Abarrant splicing of the RAS oncogenes - A new therapeutic and diagnostic approach' Congratulations Anne Mette. Thank you Emanuele Buratti (Trieste, Italy) and Luca Cartegni (Rutgers University, NJ, USA) for being external opponents and Nils J. Færgeman for acting as internal evaluator.
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January 10, 2020
PhD defence, Kathrine
Congratulations to Kathrine, who successfully defended her PhD Thesis entiteled 'Dynamic rewiring of Metabolism during Starvation in C. elegans' today. We thank the evaluation committee: external opponents Louis Lapierre (University of Brown) and Marc Pilon (University of Gothenburg) as well as internal evaluator Brage S. Andresen.
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March 16 2021
Congratulations Paolo
Congratulations to Paolo Ceppi on receiving a 10m DKK Ascending Investigator Grant from the Novo Nordisk Foundation for his work on 'Understanding and targeting the polyol pathway and fructose dependency of non-small-cell lung carcinoma'
