Homeostatic regulation of body temperature is fundamental to mammalian physiology and is controlled by acute and chronic responses of local, endocrine and neuronal regulators. Although the skin is the largest sensory organ of the human body, and plays a fundamental role in regulating body temperature, it is surprising that adaptive alterations in skin functions and morphology by far have been associated to physiological responses to temperature variations in the environment including cold. We address how mammals sense a compromised epidermal barrier and aim at understanding how barrier defects affects systemic metabolism, energy expenditure and metabolic regulations in numerous tissues.

Relevant publications

Disruption of the Acyl-CoA Binding Protein Gene Delays Hepatic Adaptation to Metabolic Changes at Weaning

Neess, D., Bloksgaard, M., Bek, S., Marcher, A., Elle, I. C., Helledie, T., Due, M., Pagmantidis, V., Finsen, B., Wilbertz,. J., Kruhøffer, M., Færgeman, N. J. and Mandrup, S. (2011)
J. Biol. Chem. 286(5)

Delayed Hepatic Adaptation to Weaning in ACBP-/- Mice is caused by Disruption of the Epidermal Barrier

Neess, D., Bek, S., Bloksgaard, M. M., Marcher, A. B., Færgeman, N. J. and Mandrup S. (2013)
Cell Reports 5(5)

Long-chain Acyl-CoA Esters in Metabolism and Signaling; Role of Acyl-CoA Binding Proteins

Neess, D., Bek, S., Engelsby, H., Gallego, S. and Færgeman, N. J. (2015)
Progress in Lipid Research 59

Regulation of Very-Long Acyl Chain Ceramide Synthesis by Acyl-CoA Binding Protein

Ferreira, N. S., Engelsby, H., Neess, D., Kelly, S. L., Volpert, G., Merrill, A. H., Futerman, A. H. and Færgeman, N. J. (2017)
J. Biol. Chem. 292(18)

The Significance of Epidermal Lipid Metabolism in Whole-Body Physiology

Kruse, V., Neess, D. and Færgeman, N. J. (2017)
Trends Endocrinol Metab. 28(9)

Epidermal Acyl-CoA-binding protein is indispensable for systemic energy homeostasis

Neess, D., Kruse, V., Marcher A. B., Wæde, M., Vistisen, J., Møller, P. M., Petersen, R., Brewer, J., B., Ma, T., Colleluori, G., Severi, I., Cinti, S., Gerhart-Hines, Z., Mandrup, S., Færgeman, N. (2021)
Molecular Metabolism 44