Factsheet by Egon Stenager

Group name: Focused Research group in neurology
Group leader: Professor Egon Stenager
Number of group members:
Associate Professor Michael Binzer
Adj. Associate Professor Ulrik Dalgas
Adj. Associate Professor Nete Munk Nielsen
Clinical associate professors: 2
Guest reasearchers: 6 (previous PhD students)
Current PhD students: 4
Up-coming PhD students: 2
Research nurses: 3

Monthly joint research meetings with Focused Resesrch Group in Psychiatry, Department of Psychiatry, Region of Southern Denmark

Department & University/Hospital/Other:
Institute of Regional Research, University of Southern Denmark and department of Neurology, Hospital of Southern Jutland.
Funding sources:
Public and private funding
Participation in international multicenter studies

Description of research:
1. Clinical epidemiological studies (primarily demyelinating CNS disorders)
2. Register-based epidemiological studies
3. Studies on the pathological and physiological basis of effect of rehabilitation
4. Neuro-psychiatric studies
5. Genetic studies (primarily in demyelinating disorders)
6. Biomarkers in L-DOPA induced dyskinesia in Parkinson´s disease
7. International multicenter studies (Phase 2, 3 and 4)


Key publications (last 10 years):
Approx. 100 peer-reviewed papers since 2008. Randomly selected:
1. Andersen AD, Blaabjerg M, Binzer M, Kamal A, Thagesen H, Kjær T, Stenager E, Gramsbergen JB. Cerebrospinal fluid levels of catecholamines and its metabolitesin Parkinson´s disease: Effect of L-DOPA treatment and changes in levodopa-induced dyskinesia. J. Neurochem 2017 Feb 28. doi: 10.1111/jnc.13997

2. Nielsen NM, Munger K, Koch-Henriksen N, Hougaard D, Magyari M, Jørgensen KT, Lunqvist M, Simonsen J, Jess T, Cohen A, Stenager E, Ascherio A. Neonatal vitamin D and risk of multiple sclerosis. A population-based case-control study. Neurology. 2017 Jan 3;88(1):44-51

3. Andersen AD, Binzer M, Stenager E, Gramsbergen JB. Cerebrospinal fluid biomarkers for Parkinson´s disease – a systematic review. Acta Neurol Scand 2017 Jan;135(1):34-56.

4. Nielsen NM, Harpsøe M, Simonsen J, Stenager E, Magyari M, Koch-Henriksen N, Sørensen TIA, Hjalgrim H, Frisch M, Bager P. Age at menarche and risk of multiple sclerosis. A retrospective cohort study based on the Danish Birth Cohort. Am J Epidemiol. 2017 Mar 25:1-8.

5. Huong Hoang, Stenager EN, Laursen B, Stenager E. Psychiatric co-morbidity in multiple sclerosis: The risk of depression and anxiety before and after MS diagnosis. Multiple Sclerosis Journal 2016;22(3):347-353

6. Binzer S, Stenager E, Binzer M, Kyvik KO, Hillert J, Imrell K. Genetic analysis of the isolated Faroe Islands reveals SORCS3 as a potential multiple sclerosis risk gene Mult Scler Jr 2016;22(6):733-40.

7. Dalgas U, Stenager E, Sloth M, Stenager EN. The effect of excercise on depressive symptoms in multiple sclerosis based on meta-analysis and critical review of literature. Eur J Neurol. 2015 Mar;22(3):443-e34

8. Jensen HB, Ravnborg M, Mamoei S, Dalgas U, Stenager E. Changes in cognition, arm function and lower body function after Slow-Release Fampridine treatment.Mult Scler. 2014;20:1872-1880.

9. Yu F, Bilberg A, Stenager E, Rabotti C, Zhang B, Mischi M. Wireless body measurement system to study fatique in multiple sclerosis. Physiol Meas 2012;33:2033-48

10. Dalgas U, Stenager E. Exercise and disease progression in multiple sclerosis – can exercise slow down the progression of multiple sclerosis? Therapeutic Advances in Neurological Disorders. 2012;5:81-95

11. Sørensen PS, Lycke J, Erälinna J-P, Edland A, Wu X, Frederiksen JL, Oturai A, Malmestöm C, Stenager E, Sellebjerg F, Søndergaard HB, Sperling B for the SIMCOMBIN Investigators. Simvastatin as add-on therapy to interferon-beta-1a for relapsing-remitting multiple sclerosis. (SIMCOMBIN Study): a placebo-controlled randomised phase 4 trial. Lancet Neurology 2011:10;691-701.

12. Asgari N, Lillevang ST, Skejø HPB, Falah M, Stenager E, Kyvik KO. Occurrence of neuromyelitis optica (NMO) in Caucasians. A population-based study. Neurology 2011;76:1581-88

13. U Dalgas, E Stenager, J Jakobsen, T Petersen, HJ Hansen, C Knudsen, K Overgaard, T Ingemann-Hansen. Resistance training improves muscle strength and functional capacity in multiple sclerosis. Neurology 2009;73:1478-84

14. McCombe P, Stenager E. Editorial: Female infertility and multiple sclerosis: is this an issue? Mult Scler J 2015 Jan;21(1):5-7.


Other outputs:
2 patents have been applied for.


Key collaborations:
Danish: All departments in the Region of Southern Denmark and all MS clinics in Denmark.
Department of Sport, Aarhus University
Department of Clinical Genetics, OUH.
SSI, Denmark
MS registry, Copenhagen

International:
Professor Alberto Acherio, Harvard
Professor Chris Heesen, Hamburg
Professor Jan Hillert, Karolinske, Stockholm
Senior Researcher Jon Stone, Edinburgh
Professor Peter Feys, Hasselt, Belgium
And several others. Please, consult publication list


Infrastructure:
Access to exercise measurements.
Neuro-epidemiology.