Factsheet by Frantz Rom Poulsen

Group name: Neurosurgical research group
Group leader: Frantz Rom Poulsen
Group members: 5 MD, PhD’s including one professor and 2 associate professors
Department & University/Hospital/Other: Department of Neurosurgery, Odense University Hospital and University of Southern Denmark
Funding sources: External funds, Region Syddanmark, Odense University Hospital

Description of research:
1. Neurosurgical oncology: improving surgical techniques (intraoperative fluorescense and MR), studies on brain cancer tumor heterogenicity including identification of new molecular markers as potential targets for treatment and as possible predictors of tumor recurrence. Outcome

2. Head trauma: risk factors for developing subdural hematomas, optimizing treatment of chronic subdural hematomas, participant in CenterTBI (a multicentre study on traumatic brain injury)

3. Vascular: Outcome after aneurism surgery or endovascular treatment. Predictors of aneurism ruptur

4. Cerebral metabolism and mitochondrial dysfunction under pathological conditions (subarachnoidal hemorhage, severe bacterial meningitis)

5. Spine: conservative management of cervical spine fractures, classification and outcome


Key publications (last 10 years):
Gaist D, García Rodríguez LA, Hellfritzsch M, Poulsen FR, Halle B, Hallas J, Pottegård A.
Association of Antithrombotic Drug Use With Subdural Hematoma Risk. JAMA. 2017 Feb 28;317(8):836-846. doi: 10.1001/jama.2017.0639.

Munthe S, Halle B, Boldt HB, Christiansen H, Schmidt S, Kaimal V, Xu J, Zabludoff S, Mollenhauer J, Poulsen FR, Kristensen BW. Shift of microRNA profile upon glioma cell migration using patient-derived spheroids and serum-free conditions. J Neurooncol. 2017 Mar;132(1):45-54.

Larsen L, Poulsen FR, Nielsen TH, Nordström CH, Schulz MK, Andersen ÅB. Use of intracranial pressure monitoring in bacterial meningitis: a 10-year follow up on outcome and intracranial pressure versus head CT scans. Infect Dis (Lond). 2017 May;49(5):356-364.

Poulsen FR, Schulz M, Jacobsen A, Andersen ÅB, Larsen L, Schalén W, Nielsen TH, Nordström C-H: Bedside evaluation of cerebral energy metabolism in severe community-acquired bacterial meningitis. Neurocrit Care. 2014 Aug 21

Poulsen FR, Halle B, Pottegård A, García Rodríguez LA, Hallas J, Gaist D. Subdural hematoma cases identified through a Danish patient register: diagnosis validity, clinical characteristics, and preadmission antithrombotic drug use. Pharmacoepidemiol Drug Saf. 2016 Nov;25(11):1253-1262.

Munthe S, Sørensen MD, Thomassen M, Burton M, Kruse TA, Lathia JD, Poulsen FR, Kristensen BW. Migrating glioma cells express stem cell markers and give rise to new tumors upon xenografting. J Neurooncol. 2016 Oct;130(1):53-62.

Andersen-Ranberg NC, Poulsen FR, Bergholt B, Hundsholt T, Fugleholm K. Bilateral chronic subdural hematoma: unilateral or bilateral drainage? J Neurosurg. 2016 Jul 8:1-7.

Thisgaard H, Halle B, Aaberg-Jessen C, Olsen BB, Therkelsen AS, Dam JH, Langkjær N, Munthe S, Någren K, Høilund-Carlsen PF, Kristensen BW. Highly Effective Auger-Electron Therapy in an Orthotopic Glioblastoma Xenograft Model using Convection-Enhanced Delivery.Theranostics. 2016 Sep 29;6(12):2278-2291

Halle B, Marcusson EG, Aaberg-Jessen C, Jensen SS, Meyer M, Schulz MK, Andersen C, Kristensen BW. Convection-enhanced delivery of an anti-miR is well-tolerated, preserves anti-miR stability and causes efficient target de-repression: a proof of concept. J Neurooncol. 2016 Jan;126(1):47-55

Mölström S, Nielsen TH, Andersen C, Nordström CH, Toft P. Bedside Monitoring of Cerebral Energy State During Cardiac Surgery-A Novel Approach Utilizing Intravenous Microdialysis. J Cardiothorac Vasc Anesth. 2016 Nov 2

Jacobsen A, Nielsen TH, Nilsson O, Schalén W, Nordström CH. Bedside diagnosis of mitochondrial dysfunction in aneurysmal subarachnoid hemorrhage. Acta Neurol Scand. 2014 Sep;130(3):156-63

Thuesen AD, Lyngsø KS, Rasmussen L, Stubbe J, Skøtt O, Poulsen FR, Pedersen CB, Rasmussen LM, Hansen PB. P/Q-type and T-type voltage-gated calcium channels are involved in the contraction of mammary and brain blood vessels from hypertensive patients. Acta Physiol (Oxf). 2017 Mar;219(3):640-651.

Munthe S, Petterson SA, Dahlrot RH, Poulsen FR, Hansen S, Kristensen BW. Glioma Cells in the Tumor Periphery Have a Stem Cell Phenotype. PLoS One. 2016 May 12;11(5)

Dahlrot RH, Poulsen FR, Nguyen NN, Kristensen BW, Hansen S, Holm NV; Academy of Geriatric Cancer Research Trends in tumors in the central nervous system in elderly in Denmark, 2008-2012. (AgeCare) Acta Oncol. 2016;55 Suppl 1:91-7.

Poulsen FR, Munthe S, Søe M, Halle B: Perindopril and residual chronic subdural hematoma volume six weeks after burr hole surgery: A randomized trial. Clin Neurol and Neurosurg. 123 (2014) 4-8


Other outputs
e.g. patents, novel therapies etc:
Patent: Auger electron therapy for glioblastoma, EP14173218.0.


Key collaborations:
Danish: Departments of Neuropathology, Neurology, Infectious Medicine, Nuclear Medicine, Radiology, Oncology, Biochemistry and Genetics at Odense University Hospital. Departments of Neurosurgery, Ålborg, Århus and Copenhagen. Basic research groups at University of Southern Denmark

International: Department of Neurosurgery, Regensburg, Germany


Infrastructure:
We are specialists in Neurosurgery and we have the possibility to use intraoperative low field MR and intraoperative fluorescense. We have close collaborations with many medical specialities (see above) and their location in the immediate vicinity makes clinical and paraclinical studies more feasible. This includes proteome and genome analysis of freshly harvested tumor samples.