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DNA/RNA research

Contact Person

Søren Feddersen, Associate Projessor, PhD, Biochemist
Soeren.Feddersen@rsyd.dkhttps://portal.findresearcher.sdu.dk/da/persons/sfeddersen

 

Research aim

We aim at discovering, validating and implementing circulating microRNAs (miRNAs) as biomarkers for early detection of disease, prediction of disease progression, and prognosis.

Project examples

  • Development and validation of a plasma miRNA signature for detection and prognostic prediction of glioblastoma.
  • Development and validation of a plasma miRNA profile for prediction of disease progression from latent tuberculosis infection to active tuberculosis. 
  • Exploring the association of circulating miRNAs in plasma to cognitive function among healthy elderly twins.
  

Collaborators, postdocs and PhD Students

  • Bjarne Winther Kristensen, Professor, Department of Pathology, Copenhagen University Hospital
  • Isik Somuncu Johansen, Professor, Department of Infectious Diseases, Odense University Hospital
  • Mads Nybo, Clinical Associate Professor, Clinical Biochemistry, Odense University Hospital
  • Lars Melholt Rasmussen, Professor, Clinical Biochemistry, Odense University Hospital
  • Jonas Mengel-From, Associate Professor, Department of Public Health, Odense University Hospital

Publication examples

  •  Mengel-From J, Feddersen S, Halekoh U, Heegaard NHH, McGue M, Christensen K, Tan Q, Christiansen L. Circulating microRNAs disclose
    biology of normal cognitive function in healthy elderly people - a discovery twin study. Eur J Hum Genet. 2018 Sep;26(9):1378-1387.
  • Steffensen LB, Feddersen S, Preil SR, Rasmussen LM. No detectable differential microRNA expression between non-atherosclerotic arteries of type 2 diabetic patients (treated or untreated with metformin) and non-diabetic patients. Cardiovasc Diabetol. 2018 May;17(1):72.

Last Updated 02.10.2024