Contact person
Pernille Just Vinholt, Associate Professor, MD, PhD, Consultant
pernille.vinholt@rsyd.dk; https://portal.findresearcher.sdu.dk/en/persons/pvinholt
Aim
Thrombosis and bleeding are common causes behind and complications to hospitalization. We aim to improve the risk assessment for thrombosis and hemostasis in order to prevent these conditions. This includes biomarker and clinical studies. Further, we are interested in both basic and translational research of the coagulation system – particularly regarding platelet function (activation and aggregation).
Project examples
- Modelling the effects of drugs on platelet function
- Establishment and use of the Danish self-assessment bleeding tool
- Development of methods for improved investigation of platelet function
- Evaluation of disease associated platelet function
Available cohorts, infrastructures and competences
We have access to state-of-the-art laboratory techniques for investigation of both primary and secondary hemostasis. Further, we have developed methods for detailed analyses of platelet function, e.g flow cytometric testing of platelet aggregation in thrombopenic samples independent of platelet count.
Collaborators, postdocs and PhD-students
The main collaborator is Department of Clinical Immunology, (Christian Nielsen, PhD, MSci).
Publication examples
- Modeling the Effects of Intravasal Administration of AstraZeneca ChAdOx1 nCoV-19 Vaccine on Human Platelets. Vinholt PJ, Frederiksen H, Nielsen C. Thromb Haemost 2021.
- Hansen RS, Carlsen M, Rasmussen KF, Vinholt PJ. Translation, validation, and usability of the International Society on Thrombosis and Haemostasis Bleeding Assessment Tool (Self-ISTH-BAT). Eur J Haematol 2021.
- Vinholt PJ, Knudsen GH, Sperling S, Frederiksen H, Nielsen C. Platelet function tests predict bleeding in patients with acute myeloid leukemia and thrombocytopenia. Am J Hematol. 2019 Aug.
- Vinholt PJ, Nybo M, Nielsen CB, Hvas AM. Light transmission aggregometry using pre-coated microtiter plates and a Victor X5 plate reader. PLoS One 2017.