Projektleder: Ole Jakob Storebø
Projects with children:
Methylphenidate for ADHD: Update of the Cochrane Review on the beneficial and harmful effects of methylphenidate in children and adolescents with ADHD.
In 2015, we published a Cochrane systematic review of the beneficial and harmful effects of methylphenidate in children and adolescents with ADHD (Storebø 2015). This review has played an essential role in the decision taken by WHO to not to include methylphenidate on the list of essential drugs for ADHD. The project has helped getting the use of methylphenidate for ADHD on the national as well as international agenda. The review is now 5 years old and will be updated in 2021. The update is important as there is still disagreement about the effects of methylphenidate.
The CARMA project: Identification of non-pharmacological factors that may have an impact on the long-term prognosis of children with ADHD as well as the general well-being of the family.
The project "CARMA" is a follow-up and continuation of the PhD project "CARPA" defense, that took place on 23.8.2018. The project builds on knowledge from previous research and centers on factors related to mother, child and the relationship between them, as there are indications in the research that these are important for general well-being in families with children with ADHD and for the child's own long-term prognosis. The overall purpose of the CARMA project is thus to identify non-pharmacological factors that may have an impact on the long-term prognosis of children with ADHD as well as the general well-being of the family.
ADHD and trigeminal nerve stimulation: Testing of external Trigeminal Nerve Stimulation System as an effective treatment strategy in children with ADHD.
In this project we test the Monarch external Trigeminal Nerve Stimulation (eTNS) System on a total of 6 children to get the first experiences in relation to the use of the device in Denmark, as well as to investigate how the children and their families experience the effect of treatment and any side effects. TNS works by stimulating the first branch of the trigeminal nerve, which can potentially modulate areas of the frontal cortex that are thought to be implicated in the symptoms of ADHD. The purpose is thus to gain insight into the device's usability, the parents' experience and the device's immediate mechanisms of action. Based on the results, a decision will be made as to whether a protocol should subsequently be prepared for a larger pilot trial, which in addition to including more participants will also include a more in-depth study of the device's effectiveness in treating ADHD in children.
Projects with children and adults:
Individualized treatment of borderline personality disorder: Individual patient data (IPD) systematic review with meta-analysis of psychotherapy for borderline personality disorder (BPD).
People with borderline personality disorder are a heterogeneous group of patients with many different clinical characteristics and thus also diverse needs for psychotherapy. It has been established that specialized psychotherapy has a positive effect on borderline symptoms, but it has not yet been possible to identify which type of psychotherapy works best on whom. The purpose of this study is to investigate whether specific clinical characteristics of the individual patient can help to predict which form of psychotherapy is best suited to the individual. This is a step towards individualized treatment in psychiatry.